{"version":"6.9","hitCount":1,"request":{"queryString":"ext_id:38290758 AND src:med","internalQuery":"ext_id:38290758 AND src:med","resultType":"CORE","cursorMark":"*","pageSize":25,"sort":"","synonym":false},"resultList":{"result":[{"id":"38290758","source":"MED","pmid":"38290758","pmcid":"PMC10870789","fullTextIdList":{"fullTextId":["PMC10870789"]},"doi":"10.1136/bmjgast-2023-001247","title":"Impact of AI-aided colonoscopy in clinical practice: a prospective randomised controlled trial.","authorString":"Schöler J, Alavanja M, de Lange T, Yamamoto S, Hedenström P, Varkey J.","authorList":{"author":[{"fullName":"Schöler J","lastName":"Schöler","firstName":"Johanna","initials":"J","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Medical Department, Sahlgrenska University Hospital, Goteborg, Sweden."}]}},{"fullName":"Alavanja M","lastName":"Alavanja","firstName":"Marko","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Goteborg, Sweden."},{"affiliation":"Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden."}]}},{"fullName":"de Lange T","lastName":"de Lange","firstName":"Thomas","initials":"T","authorId":{"type":"ORCID","value":"0000-0003-3989-7487"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Medical Department, Sahlgrenska University Hospital, Goteborg, Sweden."},{"affiliation":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Goteborg, Sweden."}]}},{"fullName":"Yamamoto S","lastName":"Yamamoto","firstName":"Shunsuke","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden."},{"affiliation":"Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan."}]}},{"fullName":"Hedenström P","lastName":"Hedenström","firstName":"Per","initials":"P","authorId":{"type":"ORCID","value":"0000-0002-4106-1454"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Medical Department, Sahlgrenska University Hospital, Goteborg, Sweden."},{"affiliation":"Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden."}]}},{"fullName":"Varkey J","lastName":"Varkey","firstName":"Jonas","initials":"J","authorId":{"type":"ORCID","value":"0000-0002-3499-7051"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Goteborg, Sweden jonas.varkey@gu.se."},{"affiliation":"Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0002-3499-7051"},{"type":"ORCID","value":"0000-0002-4106-1454"},{"type":"ORCID","value":"0000-0003-3989-7487"}]},"dataLinksTagsList":{"dataLinkstag":["altmetrics","supporting_data"]},"journalInfo":{"issue":"1","volume":"11","journalIssueId":3690732,"dateOfPublication":"2024 Jan","monthOfPublication":1,"yearOfPublication":2024,"journal":{"medlineAbbreviation":"BMJ Open Gastroenterol","title":"BMJ open gastroenterology","essn":"2054-4774","issn":"2054-4774","isoabbreviation":"BMJ Open Gastroenterol","nlmid":"101660690"},"printPublicationDate":"2024-01-01"},"pubYear":"2024","pageInfo":"e001247","abstractText":"<h4>Objective</h4>Colorectal cancer (CRC) has a significant role in cancer-related mortality. Colonoscopy, combined with adenoma removal, has proven effective in reducing CRC incidence. However, suboptimal colonoscopy quality often leads to missed polyps. The impact of artificial intelligence (AI) on adenoma and polyp detection rate (ADR, PDR) is yet to be established.<h4>Design</h4>We conducted a randomised controlled trial at Sahlgrenska University Hospital in Sweden. Patients underwent colonoscopy with or without the assistance of AI (AI-C or conventional colonoscopy (CC)). Examinations were performed with two different AI systems, that is, Fujifilm CADEye and Medtronic GI Genius. The primary outcome was ADR.<h4>Results</h4>Among 286 patients, 240 underwent analysis (average age: 66 years). The ADR was 42% for all patients, and no significant difference emerged between AI-C and CC groups (41% vs 43%). The overall PDR was 61%, with a trend towards higher PDR in the AI-C group. Subgroup analysis revealed higher detection rates for sessile serrated lesions (SSL) with AI assistance (AI-C 22%, CC 11%, p=0.004). No difference was noticed in the detection of polyps or adenomas per colonoscopy. Examinations were most often performed by experienced endoscopists, 78% (n=86 AI-C, 100 CC).<h4>Conclusion</h4>Amidst the ongoing AI integration, ADR did not improve with AI. Particularly noteworthy is the enhanced detection rates for SSL by AI assistance, especially since they pose a risk for postcolonoscopy CRC. The integration of AI into standard colonoscopy practice warrants further investigation and the development of improved software might be necessary before enforcing its mandatory implementation.<h4>Trial registration number</h4>NCT05178095.","affiliation":"Medical Department, Sahlgrenska University Hospital, Goteborg, Sweden.","publicationStatus":"epublish","language":"eng","pubModel":"Electronic","pubTypeList":{"pubType":["research-article","Randomized Controlled Trial","Journal Article"]},"meshHeadingList":{"meshHeading":[{"majorTopic_YN":"N","descriptorName":"Humans"},{"majorTopic_YN":"Y","descriptorName":"Adenoma","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"PA","qualifierName":"pathology"}]}},{"majorTopic_YN":"N","descriptorName":"Colonoscopy"},{"majorTopic_YN":"N","descriptorName":"Prospective Studies"},{"majorTopic_YN":"Y","descriptorName":"Artificial Intelligence"},{"majorTopic_YN":"N","descriptorName":"Aged"},{"majorTopic_YN":"N","descriptorName":"Early Detection of Cancer"}]},"keywordList":{"keyword":["Colonoscopy","Colorectal Cancer","Colonic Polyps","Colonic Adenomas"]},"subsetList":{"subset":[{"code":"IM","name":"Index Medicus"}]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Unpaywall","url":"https://bmjopengastro.bmj.com/content/bmjgast/11/1/e001247.full.pdf"},{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.1136/bmjgast-2023-001247"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC10870789"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC10870789?pdf=render"}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":16,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"N","hasLabsLinks":"Y","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["nct","doi"]},"dateOfCompletion":"2024-02-01","dateOfCreation":"2024-01-30","dateOfRevision":"2026-07-28","electronicPublicationDate":"2024-01-30","firstPublicationDate":"2024-01-30","firstIndexDate":"2024-01-31","fullTextReceivedDate":"2025-02-05","hasEvaluations":"N"}]}}