{"version":"6.9","hitCount":348,"nextCursorMark":"AoIIQJE/sSg1NDE3OTM0Ng==","nextPageUrl":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=ARISE AND STEMI AND electrocardiogram AND randomized&cursorMark=AoIIQJE/sSg1NDE3OTM0Ng==&resultType=core&pageSize=5&format=json","request":{"queryString":"ARISE AND STEMI AND electrocardiogram AND randomized","resultType":"core","cursorMark":"*","pageSize":5,"sort":"","synonym":false},"resultList":{"result":[{"id":"42577180","source":"MED","pmid":"42577180","pmcid":"PMC13453729","fullTextIdList":{"fullTextId":["PMC13453729"]},"doi":"10.3389/fcvm.2026.1835932","title":"Case Report: A case of successful treatment of STEMI following intra-coronary thrombolysis and re-transplantation in a heart transplant recipient.","authorString":"Kim SH, Lee SY, Chon MK, Chun KJ.","authorList":{"author":[{"fullName":"Kim SH","lastName":"Kim","firstName":"Seok Hyun","initials":"SH","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Division of Cardiology, Department of Internal Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea."}]}},{"fullName":"Lee SY","lastName":"Lee","firstName":"Soo Yong","initials":"SY","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Division of Cardiology, Department of Internal Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea."}]}},{"fullName":"Chon MK","lastName":"Chon","firstName":"Min Ku","initials":"MK","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Division of Cardiology, Department of Internal Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea."}]}},{"fullName":"Chun KJ","lastName":"Chun","firstName":"Kook Jin","initials":"KJ","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Division of Cardiology, Department of Internal Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea."}]}}]},"journalInfo":{"volume":"13","journalIssueId":4112090,"dateOfPublication":"2026 ","monthOfPublication":0,"yearOfPublication":2026,"journal":{"medlineAbbreviation":"Front Cardiovasc Med","title":"Frontiers in cardiovascular medicine","essn":"2297-055X","issn":"2297-055X","isoabbreviation":"Front Cardiovasc Med","nlmid":"101653388"},"printPublicationDate":"2026-01-01"},"pubYear":"2026","pageInfo":"1835932","abstractText":"<h4>Background</h4>The role of the Intracoronary fibrinolysis with distal occlusion (the Marinade technique) in managing refractory no-reflow during ST-segment elevation myocardial infarction in heart transplant recipients remains unknown.<h4>Case presentation</h4>We report a case of a 38-year-old heart transplant recipient who presented with anterior ST-segment elevation myocardial infarction caused by total occlusion of the proximal left anterior descending artery. Despite repeated balloon dilations and thrombus aspiration, severe refractory no-reflow persisted and was complicated by ventricular fibrillation cardiac arrest requiring venoarterial-extracorporeal membrane oxygenation (VA-ECMO) support. Rescue intracoronary fibrinolysis using the Marinade technique-consisting of distal balloon occlusion and localized alteplase delivery with a prolonged dwell time-was repeatedly performed, resulting in partial restoration of coronary flow. Additional selective distal intracoronary alteplase administration via aspiration catheter successfully re-established distal coronary perfusion and thereby allowed completion of percutaneous coronary intervention (PCI). A total intracoronary alteplase dose of 25 mg was administered without major bleeding complications, despite concurrent VA-ECMO support. Although ST-segment resolution was limited, chest pain improved and hemodynamic stabilization was achieved, enabling successful redo heart transplantation.<h4>Conclusion</h4>This case highlights the potential utility of intracoronary fibrinolysis using the Marinade technique as a bailout strategy for refractory no-reflow during PCI, even in high-risk settings such as heart transplant recipients with advanced microvascular dysfunction.","affiliation":"Division of Cardiology, Department of Internal Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.","publicationStatus":"epublish","language":"eng","pubModel":"Electronic-eCollection","pubTypeList":{"pubType":["Journal Article","Case Reports","case-report"]},"keywordList":{"keyword":["Heart transplantation","Percutaneous coronary intervention","St Elevation Myocardial Infarction","Intracoronary Fibrinolysis","Marinade Technique"]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.3389/fcvm.2026.1835932"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13453729"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13453729?pdf=render"}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":0,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"Y","hasLabsLinks":"N","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"N","dateOfCompletion":"2026-08-11","dateOfCreation":"2026-08-11","dateOfRevision":"2026-08-13","electronicPublicationDate":"2026-07-27","firstPublicationDate":"2026-07-27","firstIndexDate":"2026-08-13","fullTextReceivedDate":"2026-09-09","hasEvaluations":"N"},{"id":"42723056","source":"MED","pmid":"42723056","pmcid":"PMC13560190","fullTextIdList":{"fullTextId":["PMC13560190"]},"doi":"10.1186/s12961-026-01466-5","title":"Using evidence briefs to support future implementation planning: the case of early fibrinolysis for myocardial infarction and rehabilitation for the amputee patient in Colombia.","authorString":"Vélez M, Vélez-Marín V, Lugo-Agudelo LH, Patiño Lugo DF, Velásquez-Salazar P, Mesa Franco LF, Vera-Giraldo CY, Velásquez-Correa JC, Fahim C, Marten R, Yangchen S, Straus S.","authorList":{"author":[{"fullName":"Vélez M","lastName":"Vélez","firstName":"Marcela","initials":"M","authorId":{"type":"ORCID","value":"0000-0002-7093-2634"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia. cmarcela.velez@udea.edu.co."}]}},{"fullName":"Vélez-Marín V","lastName":"Vélez-Marín","firstName":"Viviana","initials":"V","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Lugo-Agudelo LH","lastName":"Lugo-Agudelo","firstName":"Luz Helena","initials":"LH","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Patiño Lugo DF","lastName":"Patiño Lugo","firstName":"Daniel Felipe","initials":"DF","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Velásquez-Salazar P","lastName":"Velásquez-Salazar","firstName":"Pamela","initials":"P","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Mesa Franco LF","lastName":"Mesa Franco","firstName":"Luisa Fernanda","initials":"LF","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Vera-Giraldo CY","lastName":"Vera-Giraldo","firstName":"Claudia Yaneth","initials":"CY","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Velásquez-Correa JC","lastName":"Velásquez-Correa","firstName":"Juan Carlos","initials":"JC","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia."}]}},{"fullName":"Fahim C","lastName":"Fahim","firstName":"Christine","initials":"C","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada."}]}},{"fullName":"Marten R","lastName":"Marten","firstName":"Robert","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Alliance for Health Policy and Systems Research, 20 Avenue Appia, 1211, Geneva, Switzerland."}]}},{"fullName":"Yangchen S","lastName":"Yangchen","firstName":"Sonam","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Alliance for Health Policy and Systems Research, 20 Avenue Appia, 1211, Geneva, Switzerland."}]}},{"fullName":"Straus S","lastName":"Straus","firstName":"Sharon","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0002-7093-2634"}]},"dataLinksTagsList":{"dataLinkstag":["supporting_data"]},"journalInfo":{"issue":"Suppl 1","volume":"24","journalIssueId":4260785,"dateOfPublication":"2026 Sep","monthOfPublication":9,"yearOfPublication":2026,"journal":{"medlineAbbreviation":"Health Res Policy Syst","title":"Health research policy and systems","essn":"1478-4505","issn":"1478-4505","isoabbreviation":"Health Res Policy Syst","nlmid":"101170481"},"printPublicationDate":"2026-09-01"},"pubYear":"2026","pageInfo":"70","abstractText":"<h4>Background</h4>Despite the relevance of clinical practice guidelines for health policy development, planning, evaluation and quality improvement, implementation of the Colombian national guidelines is still in early stages. The objective of this study was to develop two evidence briefs supporting future development of implementation plans.<h4>Methods</h4>We involved Colombian Ministry of Health representatives in dialogues about prioritizing recommendations for implementation. Two groups of recommendations were selected, and we developed two evidence briefs using the SUPPORT methodology's systematic process of searching and synthesizing evidence. One brief focused on providing early fibrinolysis when invasive therapy is not available promptly for patients with ST-elevation myocardial infarction (STEMI); and the second brief focused on providing rehabilitation services for individuals with amputations.<h4>Results</h4>For the evidence brief on early fibrinolysis (EF) for individuals with a STEMI, 33 articles were included. Overall, 21 studies addressed barriers, 10 addressed facilitators, and 25 focused on strategies for implementation. For the brief on rehabilitation services for persons with amputations, 45 articles were included. A total of 23 studies addressed strategies for adherence to policy recommendations in low- and middle-income countries. Moreover, 23 studies included comprehensive care and continuity of rehabilitation services for persons with amputations or patients currently experiencing or likely to experience a disability. In both briefs, we identified common facilitators and barriers for implementing recommendations. Common barriers related to patient characteristics include living in rural areas or low socioeconomic status communities. Other barriers include the lack of clinicians' training to provide EF for individuals with a STEMI and rehabilitation services for individuals with amputations. A common implementation strategy was establishing networks integrating community facilities and hospitals, with clear healthcare pathways that facilitate navigating the health system and understanding the functions of each stakeholder.<h4>Conclusions</h4>Both evidence briefs showed that in Colombia, to implement key recommendations, it is essential to improve timely access and continuity of services for populations living in rural areas and low-income settings. Evidence suggests that establishing networks integrating community facilities and hospitals might positively and significantly impact health outcomes and healthcare experience for patients with STEMI and patients with amputations who need rehabilitation services. The education sector is essential in improving the knowledge and skills of patients and healthcare providers of both conditions.","affiliation":"Faculty of Medicine, University of Antioquia, Cra 51d #62-29, Medellín, Antioquia, Colombia. cmarcela.velez@udea.edu.co.","publicationStatus":"epublish","language":"eng","pubModel":"Electronic","pubTypeList":{"pubType":["research-article","Journal Article"]},"grantsList":{"grant":[{"agency":"Alliance for Health Policy and Systems Research","orderIn":0}]},"meshHeadingList":{"meshHeading":[{"majorTopic_YN":"N","descriptorName":"Humans"},{"majorTopic_YN":"Y","descriptorName":"Myocardial Infarction","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"DT","qualifierName":"drug therapy"}]}},{"majorTopic_YN":"Y","descriptorName":"Thrombolytic Therapy"},{"majorTopic_YN":"Y","descriptorName":"Fibrinolysis"},{"majorTopic_YN":"N","descriptorName":"Health Policy"},{"majorTopic_YN":"Y","descriptorName":"Amputees","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"RH","qualifierName":"rehabilitation"}]}},{"majorTopic_YN":"N","descriptorName":"Guideline Adherence"},{"majorTopic_YN":"N","descriptorName":"Colombia"},{"majorTopic_YN":"N","descriptorName":"Practice Guidelines as Topic"},{"majorTopic_YN":"Y","descriptorName":"ST Elevation Myocardial Infarction","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"DT","qualifierName":"drug therapy"}]}},{"majorTopic_YN":"Y","descriptorName":"Amputation, Surgical","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"RH","qualifierName":"rehabilitation"}]}}]},"keywordList":{"keyword":["Rehabilitation","Implementation","Clinical Practice Guidelines","Amputee","Early Fibrinolysis"]},"subsetList":{"subset":[{"code":"IM","name":"Index Medicus"}]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.1186/s12961-026-01466-5"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13560190"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13560190?pdf=render"}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":0,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"N","hasLabsLinks":"N","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["doi"]},"dateOfCompletion":"2026-09-11","dateOfCreation":"2026-09-11","dateOfRevision":"2026-09-14","electronicPublicationDate":"2026-09-10","firstPublicationDate":"2026-09-10","firstIndexDate":"2026-09-11","fullTextReceivedDate":"2026-09-13","hasEvaluations":"N"},{"id":"41887018","source":"MED","pmid":"41887018","pmcid":"PMC13053991","fullTextIdList":{"fullTextId":["PMC13053991"]},"doi":"10.1016/j.jacadv.2026.102663","title":"AI-Enhanced Electrocardiogram for Detection of Occlusive Myocardial Infarction in High-Risk Non-ST-Segment Elevation Acute Coronary Syndrome.","authorString":"Carvalho PEP, Belzer W, Pollmann DL, Helseth HC, Traverse JH, Herman R, Mutlu D, Poulose A, Mooney M, Burke MN, Voudris K, Goessl M, Chavez I, Wang YL, Strepkos D, Alexandrou M, Cravero E, Rangan BV, Jaffe AS, Brilakis ES, Sharkey SW, Sandoval Y.","authorList":{"author":[{"fullName":"Carvalho PEP","lastName":"Carvalho","firstName":"Pedro E P","initials":"PEP","authorId":{"type":"ORCID","value":"0000-0002-0918-6759"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Belzer W","lastName":"Belzer","firstName":"Will","initials":"W","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Pollmann DL","lastName":"Pollmann","firstName":"Daniel L","initials":"DL","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Internal Medicine, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Helseth HC","lastName":"Helseth","firstName":"Hans C","initials":"HC","authorId":{"type":"ORCID","value":"0009-0005-3282-9504"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Emergency Department, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Traverse JH","lastName":"Traverse","firstName":"Jay H","initials":"JH","authorId":{"type":"ORCID","value":"0000-0002-2108-0252"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Herman R","lastName":"Herman","firstName":"Robert","initials":"R","authorId":{"type":"ORCID","value":"0000-0002-8773-1732"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Cardiovascular Center Aalst, AZORG, Aalst, Belgium; Powerful Medical, Bratislava, Slovakia."}]}},{"fullName":"Mutlu D","lastName":"Mutlu","firstName":"Deniz","initials":"D","authorId":{"type":"ORCID","value":"0000-0003-4432-4595"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Poulose A","lastName":"Poulose","firstName":"Anil","initials":"A","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Mooney M","lastName":"Mooney","firstName":"Michael","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Burke MN","lastName":"Burke","firstName":"M Nicholas","initials":"MN","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Voudris K","lastName":"Voudris","firstName":"Konstantinos","initials":"K","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Goessl M","lastName":"Goessl","firstName":"Mario","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Chavez I","lastName":"Chavez","firstName":"Ivan","initials":"I","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Wang YL","lastName":"Wang","firstName":"Yale L","initials":"YL","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Strepkos D","lastName":"Strepkos","firstName":"Dimitrios","initials":"D","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Alexandrou M","lastName":"Alexandrou","firstName":"Michaella","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Cravero E","lastName":"Cravero","firstName":"Ellen","initials":"E","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Biostatistic Unit, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Rangan BV","lastName":"Rangan","firstName":"Bavana V","initials":"BV","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Jaffe AS","lastName":"Jaffe","firstName":"Allan S","initials":"AS","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Cardiovascular Medicine and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA."}]}},{"fullName":"Brilakis ES","lastName":"Brilakis","firstName":"Emmanouil S","initials":"ES","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA; Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA."}]}},{"fullName":"Sharkey SW","lastName":"Sharkey","firstName":"Scott W","initials":"SW","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA."}]}},{"fullName":"Sandoval Y","lastName":"Sandoval","firstName":"Yader","initials":"Y","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA; Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA. Electronic address: yadersandoval@gmail.com."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0002-0918-6759"},{"type":"ORCID","value":"0000-0002-2108-0252"},{"type":"ORCID","value":"0000-0002-8773-1732"},{"type":"ORCID","value":"0000-0003-4432-4595"},{"type":"ORCID","value":"0009-0005-3282-9504"}]},"dataLinksTagsList":{"dataLinkstag":["altmetrics","supporting_data"]},"journalInfo":{"issue":"4","volume":"5","journalIssueId":4184423,"dateOfPublication":"2026 Apr","monthOfPublication":4,"yearOfPublication":2026,"journal":{"medlineAbbreviation":"JACC Adv","title":"JACC. Advances","essn":"2772-963X","issn":"2772-963X","isoabbreviation":"JACC Adv","nlmid":"9918419284106676"},"printPublicationDate":"2026-04-01"},"pubYear":"2026","pageInfo":"102663","abstractText":"<h4>Background</h4>Whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) improves detection of occlusive myocardial infarction (OMI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) compared with standard of care (SOC) remains uncertain.<h4>Objectives</h4>The objective of the study was to evaluate an AI-ECG model for detecting OMI among patients with suspected high-risk NSTE-ACS using invasive coronary angiography (ICA) as the reference.<h4>Methods</h4>Consecutive adults undergoing emergent ICA under the institutional level 2 protocol for suspected high-risk NSTE-ACS (2022-2024) were included. Patients with ST-elevation myocardial infarction were excluded. Initial 12-lead ECGs were retrospectively analyzed using an investigational AI-ECG model (Queen of Hearts, Powerful Medical) validated against ICA findings. OMI was defined as an angiographic culprit lesion with TIMI flow grade 0 to 2 or TIMI flow grade 3 with marked troponin elevation or new regional wall motion abnormality.<h4>Results</h4>Among 224 patients, OMI was present in 129 (58%). AI-ECG identified 75 (58%) of these as OMI and classified 96 patients (43%) as OMI overall. For rule in, specificity was 78% (95% CI: 68%-86%) and positive predictive value 78% (95% CI: 69%-86%). For rule out, sensitivity was 58% (95% CI: 49%-66%) and negative predictive value 57% (95% CI: 48%-66%). Serial ECGs reduced false negatives from 42% to 34%. Compared with the standard of care, an AI-augmented triage approach reduced false positives from 42% to 22% (P < 0.001).<h4>Conclusions</h4>In high-risk NSTE-ACS, AI-ECG improved rule in accuracy for OMI, potentially enhancing early identification of patients requiring urgent ICA. However, rule out performance from initial ECG alone was limited, supporting the need for serial ECGs and clinical judgment.","affiliation":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.","publicationStatus":"ppublish","language":"eng","pubModel":"Print-Electronic","pubTypeList":{"pubType":["research-article","Journal Article"]},"grantsList":{"grant":[{"agency":"American Heart Association Inc","orderIn":0}]},"keywordList":{"keyword":["Artificial intelligence","Electrocardiogram","Non–st-segment Elevation Myocardial Infarction","Non–st-segment Elevation Acute Coronary Syndrome"]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.1016/j.jacadv.2026.102663"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13053991"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC13053991?pdf=render"}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":2,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"Y","hasLabsLinks":"Y","hasData":"Y","license":"cc by-nc-nd","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["doi"]},"dateOfCompletion":"2026-04-23","dateOfCreation":"2026-03-26","dateOfRevision":"2026-08-13","electronicPublicationDate":"2026-03-25","firstPublicationDate":"2026-03-25","firstIndexDate":"2026-03-27","fullTextReceivedDate":"2026-04-08","hasEvaluations":"N"},{"id":"41517565","source":"MED","pmid":"41517565","pmcid":"PMC12786525","fullTextIdList":{"fullTextId":["PMC12786525"]},"doi":"10.3390/jcm15010316","title":"AI Applications in Electrocardiography for Ischemic and Structural Heart Disease: A Review of the Current State.","authorString":"Kim EJ, Gala D, Ayyad M, Pramanik M, Makaryus AN.","authorList":{"author":[{"fullName":"Kim EJ","lastName":"Kim","firstName":"Eugene J","initials":"EJ","authorId":{"type":"ORCID","value":"0000-0002-1316-5459"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07003, USA."}]}},{"fullName":"Gala D","lastName":"Gala","firstName":"Dhir","initials":"D","authorId":{"type":"ORCID","value":"0000-0003-1410-8576"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07003, USA."}]}},{"fullName":"Ayyad M","lastName":"Ayyad","firstName":"Mohammed","initials":"M","authorId":{"type":"ORCID","value":"0000-0001-9772-2365"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07003, USA."}]}},{"fullName":"Pramanik M","lastName":"Pramanik","firstName":"Manaal","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"W. Tresper Clarke School, Salisbury, NY 11590, USA."}]}},{"fullName":"Makaryus AN","lastName":"Makaryus","firstName":"Amgad N","initials":"AN","authorId":{"type":"ORCID","value":"0000-0003-2104-7230"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Cardiology, Cardiovascular Institute, Northwell Health, New Hyde Park, NY 11040, USA."},{"affiliation":"Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA."},{"affiliation":"Plainview Hospital, Northwell Health, Plainview, NY 11803, USA."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0001-9772-2365"},{"type":"ORCID","value":"0000-0002-1316-5459"},{"type":"ORCID","value":"0000-0003-1410-8576"},{"type":"ORCID","value":"0000-0003-2104-7230"}]},"dataLinksTagsList":{"dataLinkstag":["supporting_data"]},"journalInfo":{"issue":"1","volume":"15","journalIssueId":4089951,"dateOfPublication":"2026 Jan","monthOfPublication":1,"yearOfPublication":2026,"journal":{"medlineAbbreviation":"J Clin Med","title":"Journal of clinical medicine","essn":"2077-0383","issn":"2077-0383","isoabbreviation":"J Clin Med","nlmid":"101606588"},"printPublicationDate":"2026-01-01"},"pubYear":"2026","pageInfo":"316","abstractText":"Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with ischemic and structural heart diseases being key contributors. While the 12-lead electrocardiogram (ECG) is a common low-cost diagnostic test, its interpretation is limited by human variability. Through machine learning with large diverse ECG data sets and artificial intelligence (AI) algorithms, ECG analysis can be automated for pattern recognition with higher accuracy. AI-augmented ECG algorithms have been demonstrated to be able to detect myocardial infarction with high accuracy and reduce door-to-balloon coronary intervention times. Similar models can be utilized to detect subtle ECG waveforms suggestive of current or future asymptomatic left ventricular dysfunction, aortic stenosis, and hypertrophic cardiomyopathy. Despite these promising results, there is concern for generalizability and bias or errors in training data. As AI systems evolve to multimodal integration, AI-augmented ECG has the potential to redefine cardiovascular diagnostics and enable earlier detection, risk stratification, and precision-guided interventions.","affiliation":"Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07003, USA.","publicationStatus":"epublish","language":"eng","pubModel":"Electronic","pubTypeList":{"pubType":["review-article","Review","Journal Article"]},"keywordList":{"keyword":["Artificial intelligence","Electrocardiography","hypertrophic cardiomyopathy","AI","Cardiology","Aortic Stenosis","Stemi","Nstemi","Omi","Deep Learning"]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.3390/jcm15010316"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12786525"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12786525?pdf=render"}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":3,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"N","hasLabsLinks":"N","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["doi"]},"dateOfCompletion":"2026-01-10","dateOfCreation":"2026-01-10","dateOfRevision":"2026-01-13","electronicPublicationDate":"2026-01-01","firstPublicationDate":"2026-01-01","firstIndexDate":"2026-01-13","fullTextReceivedDate":"2026-01-10","hasEvaluations":"N"},{"id":"41195776","source":"MED","pmid":"41195776","pmcid":"PMC12887225","fullTextIdList":{"fullTextId":["PMC12887225"]},"doi":"10.1161/jaha.125.041993","title":"Reduction of Thrombus Burden With Short-Term, Low-Dose Rivaroxaban Use in Acute Myocardial Infarction: The ARISE-ARMYDA 7 Randomized Trial.","authorString":"Mennuni MG, Grisafi L, Anastasia G, Solli M, Galiffa V, Villa M, Bosco M, Incaminato E, Rosso R, De Crescenzo F, D'Amario D, Vergallo R, Rippa R, Patti G.","authorList":{"author":[{"fullName":"Mennuni MG","lastName":"Mennuni","firstName":"Marco G","initials":"MG","authorId":{"type":"ORCID","value":"0000-0002-3795-8787"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."},{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"Grisafi L","lastName":"Grisafi","firstName":"Leonardo","initials":"L","authorId":{"type":"ORCID","value":"0000-0001-5277-9907"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"Anastasia G","lastName":"Anastasia","firstName":"Gianluca","initials":"G","authorId":{"type":"ORCID","value":"0009-0001-0762-5551"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Internal Medicine and Medical Specialties University of Genoa Genoa Italy."},{"affiliation":"IRCCS San Martino Polyclinic Hospital Genoa Italy."}]}},{"fullName":"Solli M","lastName":"Solli","firstName":"Martina","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"Galiffa V","lastName":"Galiffa","firstName":"Vincenzo","initials":"V","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"Villa M","lastName":"Villa","firstName":"Matilde","initials":"M","authorId":{"type":"ORCID","value":"0009-0004-2628-9794"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."}]}},{"fullName":"Bosco M","lastName":"Bosco","firstName":"Manuel","initials":"M","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."}]}},{"fullName":"Incaminato E","lastName":"Incaminato","firstName":"Enrico","initials":"E","authorId":{"type":"ORCID","value":"0000-0003-0525-4643"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."}]}},{"fullName":"Rosso R","lastName":"Rosso","firstName":"Roberta","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."},{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"De Crescenzo F","lastName":"De Crescenzo","firstName":"Francesco","initials":"F","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"D'Amario D","lastName":"D'Amario","firstName":"Domenico","initials":"D","authorId":{"type":"ORCID","value":"0000-0003-3774-8330"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."},{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}},{"fullName":"Vergallo R","lastName":"Vergallo","firstName":"Rocco","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Internal Medicine and Medical Specialties University of Genoa Genoa Italy."},{"affiliation":"IRCCS San Martino Polyclinic Hospital Genoa Italy."}]}},{"fullName":"Rippa R","lastName":"Rippa","firstName":"Rebecca","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Internal Medicine and Medical Specialties University of Genoa Genoa Italy."},{"affiliation":"IRCCS San Martino Polyclinic Hospital Genoa Italy."}]}},{"fullName":"Patti G","lastName":"Patti","firstName":"Giuseppe","initials":"G","authorId":{"type":"ORCID","value":"0000-0002-5404-3968"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy."},{"affiliation":"Maggiore della Carità Hospital Novara Italy."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0001-5277-9907"},{"type":"ORCID","value":"0000-0002-3795-8787"},{"type":"ORCID","value":"0000-0002-5404-3968"},{"type":"ORCID","value":"0000-0003-0525-4643"},{"type":"ORCID","value":"0000-0003-3774-8330"},{"type":"ORCID","value":"0009-0001-0762-5551"},{"type":"ORCID","value":"0009-0004-2628-9794"}]},"dataLinksTagsList":{"dataLinkstag":["supporting_data"]},"journalInfo":{"issue":"22","volume":"14","journalIssueId":4051112,"dateOfPublication":"2025 Nov","monthOfPublication":11,"yearOfPublication":2025,"journal":{"medlineAbbreviation":"J Am Heart Assoc","title":"Journal of the American Heart Association","essn":"2047-9980","issn":"2047-9980","isoabbreviation":"J Am Heart Assoc","nlmid":"101580524"},"printPublicationDate":"2025-11-01"},"pubYear":"2025","pageInfo":"e041993","abstractText":"<h4>Background</h4>Managing large coronary thrombus burden (LCTB) in patients with ST-segment-elevation myocardial infarction (STEMI) remains challenging. Although deferred stenting emerged to potentially improve outcomes in this high-risk population, the optimal antithrombotic regimen remains unclear. The ARISE-ARMYDA 7 (Alternative Anti-Thrombotic Pathways in Acute Myocardial Infarction-Antiplatelet Therapy for Reduction of Myocardial Damage 7) trial evaluated low-dose rivaroxaban in addition to dual antiplatelet therapy for LCTB reduction in patients with STEMI managed with deferred stenting.<h4>Methods</h4>This single-center, randomized, pilot study included patients with STEMI with angiographic evidence of LCTB undergoing primary percutaneous coronary intervention and deferred stenting. Patients were randomized to rivaroxaban 2.5 mg BID plus aspirin and ticagrelor or aspirin plus ticagrelor alone. Thrombus burden was assessed by optical coherence tomography at baseline and after 5 to 7 days of treatment. The primary end point was reduction of thrombus score after this period.<h4>Results</h4>A total of 40 patients with STEMI and LCTB were randomized 1:1. Posttreatment thrombus score at re-optical coherence tomography imaging was significantly lower in the rivaroxaban arm (39 [27-52] versus 82 [50-111] in controls, <i>P</i>=0.005). Relative reduction of the thrombus score versus baseline was greater with rivaroxaban use (61% [50%-81%] versus 36% [0%-50%], <i>P</i>=0.002). The relative thrombus volume decrease was 77% with rivaroxaban versus 39% in the control arm (<i>P</i>=0.001). Deferred stenting was safe, with no abrupt vessel closures, distal embolization, or no reflow. Clinical outcomes at 30 days, including major adverse cardiovascular events and bleeding complications, were not significantly different.<h4>Conclusions</h4>The ARISE-ARMYDA 7 trial shows that adding low-dose rivaroxaban to dual antiplatelet therapy significantly reduces thrombus burden in patients with STEMI with LCTB, while maintaining a favorable safety profile.<h4>Registration</h4>URL: https://www.clinicaltrialsregister.eu/; Unique identifier: EudraCT 2020-005156-38.","affiliation":"Department of Translational Medicine University of Eastern Piedmont Novara Italy.","publicationStatus":"ppublish","language":"eng","pubModel":"Print-Electronic","pubTypeList":{"pubType":["Research Support, Non-U.S. Gov't","research-article","Randomized Controlled Trial","Journal Article"]},"meshHeadingList":{"meshHeading":[{"majorTopic_YN":"N","descriptorName":"Humans"},{"majorTopic_YN":"Y","descriptorName":"Coronary Thrombosis","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"DG","qualifierName":"diagnostic imaging"},{"majorTopic_YN":"N","abbreviation":"DT","qualifierName":"drug therapy"},{"majorTopic_YN":"N","abbreviation":"TH","qualifierName":"therapy"}]}},{"majorTopic_YN":"N","descriptorName":"Aspirin","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"AD","qualifierName":"administration & dosage"}]}},{"majorTopic_YN":"N","descriptorName":"Platelet Aggregation Inhibitors","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"AD","qualifierName":"administration & dosage"},{"majorTopic_YN":"N","abbreviation":"AE","qualifierName":"adverse effects"}]}},{"majorTopic_YN":"N","descriptorName":"Coronary Angiography"},{"majorTopic_YN":"N","descriptorName":"Tomography, Optical Coherence"},{"majorTopic_YN":"N","descriptorName":"Treatment Outcome"},{"majorTopic_YN":"N","descriptorName":"Drug Therapy, Combination"},{"majorTopic_YN":"N","descriptorName":"Pilot Projects"},{"majorTopic_YN":"N","descriptorName":"Time Factors"},{"majorTopic_YN":"N","descriptorName":"Aged"},{"majorTopic_YN":"N","descriptorName":"Middle Aged"},{"majorTopic_YN":"N","descriptorName":"Female"},{"majorTopic_YN":"N","descriptorName":"Male"},{"majorTopic_YN":"N","descriptorName":"Percutaneous Coronary Intervention"},{"majorTopic_YN":"Y","descriptorName":"Factor Xa Inhibitors","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"AD","qualifierName":"administration & dosage"},{"majorTopic_YN":"N","abbreviation":"AE","qualifierName":"adverse effects"}]}},{"majorTopic_YN":"Y","descriptorName":"Rivaroxaban","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"AD","qualifierName":"administration & dosage"},{"majorTopic_YN":"N","abbreviation":"AE","qualifierName":"adverse effects"}]}},{"majorTopic_YN":"Y","descriptorName":"ST Elevation Myocardial Infarction","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"DG","qualifierName":"diagnostic imaging"},{"majorTopic_YN":"N","abbreviation":"DI","qualifierName":"diagnosis"},{"majorTopic_YN":"N","abbreviation":"TH","qualifierName":"therapy"}]}},{"majorTopic_YN":"N","descriptorName":"Ticagrelor","meshQualifierList":{"meshQualifier":[{"majorTopic_YN":"N","abbreviation":"AD","qualifierName":"administration & dosage"}]}}]},"keywordList":{"keyword":["Percutaneous coronary intervention","Stemi","optical coherence tomography","Rivaroxaban","Thrombus Burden"]},"chemicalList":{"chemical":[{"name":"Platelet Aggregation Inhibitors","registryNumber":"0"},{"name":"Aspirin","registryNumber":"R16CO5Y76E"},{"name":"Factor Xa Inhibitors","registryNumber":"0"},{"name":"rivaroxaban","registryNumber":"9NDF7JZ4M3"},{"name":"Ticagrelor","registryNumber":"GLH0314RVC"}]},"subsetList":{"subset":[{"code":"IM","name":"Index Medicus"}]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.1161/JAHA.125.041993"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12887225"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12887225?pdf=render"}]},"commentCorrectionList":{"commentCorrection":[{"source":"MED","id":"41195794","reference":"J Am Heart Assoc. 2025 Nov 18;14(22):e046295. doi: 10.1161/JAHA.125.046295.","type":"Comment in","orderIn":1}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":2,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"Y","hasLabsLinks":"N","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["eudract"]},"dateOfCompletion":"2025-11-19","dateOfCreation":"2025-11-06","dateOfRevision":"2026-08-29","electronicPublicationDate":"2025-11-06","firstPublicationDate":"2025-11-06","firstIndexDate":"2025-11-06","fullTextReceivedDate":"2026-02-14","hasEvaluations":"N"}]}}