{"version":"6.9","hitCount":1,"request":{"queryString":"ext_id:41226043 AND src:med","internalQuery":"ext_id:41226043 AND src:med","resultType":"CORE","cursorMark":"*","pageSize":25,"sort":"","synonym":false},"resultList":{"result":[{"id":"41226043","source":"MED","pmid":"41226043","pmcid":"PMC12607807","fullTextIdList":{"fullTextId":["PMC12607807"]},"doi":"10.3390/diagnostics15212751","title":"Clinical Evaluation of PolyDeep, A Computer-Aided Detection System: A Multicenter Randomized Tandem Colonoscopy Trial.","authorString":"Davila-Piñón P, Díez Martín AI, Nogueira-Rodríguez A, Domínguez-Carbajales R, Fdez-Riverola F, Zarraquiños S, de Castro L, Herrero J, Fernández N, Vega P, Remedios D, Martínez A, Puga M, Alonso S, Pin N, García-Morales N, Rivas L, Ledo A, Macenlle R, Cid L, Rodríguez A, Soto S, Baiocchi F, Pérez-Medrano I, Sánchez E, Glez-Peña D, Reboiro-Jato M, López-Fernández H, Cubiella J.","authorList":{"author":[{"fullName":"Davila-Piñón P","lastName":"Davila-Piñón","firstName":"Pedro","initials":"P","authorId":{"type":"ORCID","value":"0000-0002-3268-4051"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Research Group in Gastrointestinal Oncology Ourense, University Hospital of Ourense, 32005 Ourense, Spain."},{"affiliation":"Fundación Pública Galega de Investigación Biomédica Galicia Sur, Hospital Universitario de Ourense, Servicio Gallego de Salud (SERGAS), 32005 Ourense, Spain."}]}},{"fullName":"Díez Martín AI","lastName":"Díez Martín","firstName":"Astrid Irene","initials":"AI","authorId":{"type":"ORCID","value":"0000-0001-8822-2991"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Research Group in Gastrointestinal Oncology Ourense, University Hospital of Ourense, 32005 Ourense, Spain."},{"affiliation":"Fundación Pública Galega de Investigación Biomédica Galicia Sur, Hospital Universitario de Ourense, Servicio Gallego de Salud (SERGAS), 32005 Ourense, Spain."}]}},{"fullName":"Nogueira-Rodríguez A","lastName":"Nogueira-Rodríguez","firstName":"Alba","initials":"A","authorId":{"type":"ORCID","value":"0000-0001-5991-7698"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Computer Science, ESEI-Escuela Superior de Ingeniería Informática, Universidade de Vigo, 32004 Ourense, Spain."},{"affiliation":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Servicio Gallego de Salud (SERGAS)-Universidad de Vigo (UVIGO), 32004 Ourense, Spain."}]}},{"fullName":"Domínguez-Carbajales R","lastName":"Domínguez-Carbajales","firstName":"Ruben","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of IT, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Fdez-Riverola F","lastName":"Fdez-Riverola","firstName":"Florentino","initials":"F","authorId":{"type":"ORCID","value":"0000-0002-3943-8013"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Computer Science, ESEI-Escuela Superior de Ingeniería Informática, Universidade de Vigo, 32004 Ourense, Spain."},{"affiliation":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Servicio Gallego de Salud (SERGAS)-Universidad de Vigo (UVIGO), 32004 Ourense, Spain."}]}},{"fullName":"Zarraquiños S","lastName":"Zarraquiños","firstName":"Sara","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"de Castro L","lastName":"de Castro","firstName":"Luisa","initials":"L","authorId":{"type":"ORCID","value":"0000-0001-7848-7910"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Herrero J","lastName":"Herrero","firstName":"Jesús","initials":"J","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Fernández N","lastName":"Fernández","firstName":"Nereida","initials":"N","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Vega P","lastName":"Vega","firstName":"Pablo","initials":"P","authorId":{"type":"ORCID","value":"0000-0001-7545-6297"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Remedios D","lastName":"Remedios","firstName":"David","initials":"D","authorId":{"type":"ORCID","value":"0000-0003-2682-0317"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Martínez A","lastName":"Martínez","firstName":"Alfonso","initials":"A","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Puga M","lastName":"Puga","firstName":"Manuel","initials":"M","authorId":{"type":"ORCID","value":"0000-0003-4898-3889"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Alonso S","lastName":"Alonso","firstName":"Sara","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Pin N","lastName":"Pin","firstName":"Noel","initials":"N","authorId":{"type":"ORCID","value":"0000-0003-0526-4104"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"García-Morales N","lastName":"García-Morales","firstName":"Natalia","initials":"N","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Rivas L","lastName":"Rivas","firstName":"Laura","initials":"L","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Ledo A","lastName":"Ledo","firstName":"Alejandro","initials":"A","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, Complexo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain."}]}},{"fullName":"Macenlle R","lastName":"Macenlle","firstName":"Ramiro","initials":"R","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Cid L","lastName":"Cid","firstName":"Lucia","initials":"L","authorId":{"type":"ORCID","value":"0000-0001-5082-652X"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Rodríguez A","lastName":"Rodríguez","firstName":"Antonio","initials":"A","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}},{"fullName":"Soto S","lastName":"Soto","firstName":"Santiago","initials":"S","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Baiocchi F","lastName":"Baiocchi","firstName":"Franco","initials":"F","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Pérez-Medrano I","lastName":"Pérez-Medrano","firstName":"Indhira","initials":"I","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, Complexo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain."},{"affiliation":"Instituto de Investigación Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain."}]}},{"fullName":"Sánchez E","lastName":"Sánchez","firstName":"Eloy","initials":"E","authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Gastroenterology, University Hospital of Ourense, 32005 Ourense, Spain."}]}},{"fullName":"Glez-Peña D","lastName":"Glez-Peña","firstName":"Daniel","initials":"D","authorId":{"type":"ORCID","value":"0000-0002-6129-7245"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Computer Science, ESEI-Escuela Superior de Ingeniería Informática, Universidade de Vigo, 32004 Ourense, Spain."},{"affiliation":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Servicio Gallego de Salud (SERGAS)-Universidad de Vigo (UVIGO), 32004 Ourense, Spain."}]}},{"fullName":"Reboiro-Jato M","lastName":"Reboiro-Jato","firstName":"Miguel","initials":"M","authorId":{"type":"ORCID","value":"0000-0001-8749-2703"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Computer Science, ESEI-Escuela Superior de Ingeniería Informática, Universidade de Vigo, 32004 Ourense, Spain."},{"affiliation":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Servicio Gallego de Salud (SERGAS)-Universidad de Vigo (UVIGO), 32004 Ourense, Spain."}]}},{"fullName":"López-Fernández H","lastName":"López-Fernández","firstName":"Hugo","initials":"H","authorId":{"type":"ORCID","value":"0000-0002-6476-7206"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Department of Computer Science, ESEI-Escuela Superior de Ingeniería Informática, Universidade de Vigo, 32004 Ourense, Spain."},{"affiliation":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Servicio Gallego de Salud (SERGAS)-Universidad de Vigo (UVIGO), 32004 Ourense, Spain."}]}},{"fullName":"Cubiella J","lastName":"Cubiella","firstName":"Joaquín","initials":"J","authorId":{"type":"ORCID","value":"0000-0002-9994-4831"},"authorAffiliationDetailsList":{"authorAffiliation":[{"affiliation":"Research Group in Gastrointestinal Oncology Ourense, University Hospital of Ourense, 32005 Ourense, Spain."},{"affiliation":"Department of Gastroenterology, University Hospital Álvaro Cunqueiro of Vigo, 36312 Vigo, Spain."}]}}]},"authorIdList":{"authorId":[{"type":"ORCID","value":"0000-0001-5082-652X"},{"type":"ORCID","value":"0000-0001-5991-7698"},{"type":"ORCID","value":"0000-0001-7545-6297"},{"type":"ORCID","value":"0000-0001-7848-7910"},{"type":"ORCID","value":"0000-0001-8749-2703"},{"type":"ORCID","value":"0000-0001-8822-2991"},{"type":"ORCID","value":"0000-0002-3268-4051"},{"type":"ORCID","value":"0000-0002-3943-8013"},{"type":"ORCID","value":"0000-0002-6129-7245"},{"type":"ORCID","value":"0000-0002-6476-7206"},{"type":"ORCID","value":"0000-0002-9994-4831"},{"type":"ORCID","value":"0000-0003-0526-4104"},{"type":"ORCID","value":"0000-0003-2682-0317"},{"type":"ORCID","value":"0000-0003-4898-3889"}]},"dataLinksTagsList":{"dataLinkstag":["altmetrics","supporting_data"]},"journalInfo":{"issue":"21","volume":"15","journalIssueId":4048095,"dateOfPublication":"2025 Oct","monthOfPublication":10,"yearOfPublication":2025,"journal":{"medlineAbbreviation":"Diagnostics (Basel)","title":"Diagnostics (Basel, Switzerland)","essn":"2075-4418","issn":"2075-4418","nlmid":"101658402","isoabbreviation":"Diagnostics (Basel)"},"printPublicationDate":"2025-10-01"},"pubYear":"2025","pageInfo":"2751","abstractText":"<b>Background/Objectives</b>: Computer-aided detection (CADe) systems are increasingly used in endoscopy to enhance lesion recognition. PolyDeep is a CADe/x tool previously assessed in an observational study. The aim of our study is to determine if PolyDeep-assisted colonoscopy reduces the adenoma miss rate (AMR) compared with conventional colonoscopy. <b>Methods</b>: We carried out a multicenter randomized controlled trial with a tandem colonoscopy design in participants from a colorectal cancer screening program (positive fecal immunochemical test-FIT or surveillance). Expert endoscopists performed all colonoscopies, and patients were allocated to groups by a computer-generated sequence. The primary endpoint was AMR; secondary endpoints included polyp miss rate (PMR), serrated lesion miss rate (SLMR) and advanced polyp miss rate (APMR). <b>Results</b>: From May to November 2023, we recruited 260 patients and excluded 20, leaving 240 for analysis. Baseline characteristics were balanced between groups (62.1% male; mean age 62.3 ± 6.5 years; 65.8% FIT-positive; mean first withdrawal time 13:38 ± 08:07 min; mean second withdrawal time 07:50 ± 03:38 min; lesion detection rate 76.6%; mean polyps per patient 3.4 ± 3.1). We did not find statistically significant differences between PolyDeep-assisted and conventional colonoscopy groups in AMR (21.3% vs. 18.1%, <i>p</i> = 0.5), PMR (21.8% vs. 20.3%, <i>p</i> = 0.7), SLMR (23.4% vs. 25.6%, <i>p</i> = 0.9) or APMR (7.3% vs. 11.3%, <i>p</i> = 0.5). In the subgroup analysis according to indication, we did not find any statistically significant differences. <b>Conclusions</b>: In the context of a CRC screening program, PolyDeep-assisted colonoscopy did not reduce AMR.","affiliation":"Research Group in Gastrointestinal Oncology Ourense, University Hospital of Ourense, 32005 Ourense, Spain.","publicationStatus":"epublish","language":"eng","pubModel":"Electronic","pubTypeList":{"pubType":["research-article","Journal Article"]},"grantsList":{"grant":[{"agency":"ERDF A way of making Europe","grantId":"DPI2017-87494-R","orderIn":0},{"agency":"Spanish Association of Gastroenterology","grantId":"Grant of Oncology-Tamarite 2022","orderIn":0},{"agency":"European Union NextGenerationEU/PRTR","grantId":"PDC2021-121644-I00","orderIn":0},{"agency":"Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia)","grantId":"ED431G 2019/06, ED431C 2022/03-GRC and ED481B-2023-005","orderIn":0},{"agency":"MICIU/AEI/10.13039/501100011033","grantId":"PDC2021-121644-I00","orderIn":0},{"agency":"MICIU/AEI/10.13039/501100011033","grantId":"DPI2017-87494-R","orderIn":0},{"agency":"Instituto de Salud Carlos III","grantId":"PI21/01771, CD22/00087 and INT22/00009, FI22/00203","orderIn":0}]},"keywordList":{"keyword":["Screening","Surveillance","Colorectal Cancer","Polyp Detection","Adenoma Miss Rate","Colonoscopy Quality","Cade","Tandem Colonoscopy","Advanced Polyps","Positive Fit"]},"fullTextUrlList":{"fullTextUrl":[{"availability":"Subscription required","availabilityCode":"S","documentStyle":"doi","site":"DOI","url":"https://doi.org/10.3390/diagnostics15212751"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"html","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12607807"},{"availability":"Open access","availabilityCode":"OA","documentStyle":"pdf","site":"Europe_PMC","url":"https://europepmc.org/articles/PMC12607807?pdf=render"}]},"commentCorrectionList":{"commentCorrection":[{"source":"PPR","id":"PPR1084155","type":"Preprint in","note":"Link created based on a title-first author match","orderIn":10002}]},"isOpenAccess":"Y","inEPMC":"Y","inPMC":"Y","citedByCount":2,"hasReferences":"Y","hasTextMinedTerms":"Y","hasDbCrossReferences":"N","hasPDF":"Y","hasBook":"N","hasSuppl":"N","hasLabsLinks":"Y","hasData":"Y","license":"cc by","authMan":"N","epmcAuthMan":"N","nihAuthMan":"N","hasTMAccessionNumbers":"Y","tmAccessionTypeList":{"accessionType":["nct","doi"]},"dateOfCompletion":"2025-11-13","dateOfCreation":"2025-11-13","dateOfRevision":"2025-11-15","electronicPublicationDate":"2025-10-30","firstPublicationDate":"2025-10-30","firstIndexDate":"2025-11-14","fullTextReceivedDate":"2025-12-22","hasEvaluations":"N"}]}}